Translational Neurosurgery Laboratory
Vision
The Translational Neurosurgery Laboratory's mission is to develop new neuro-technologies to modulate brain activity and unlock next-generation tools for clinicians treating patients suffering from brain diseases.
We are working at the interface of psychology, engineering, gene therapy and neurosurgery.
Our team is optimizing the following technologies to help understand and modulate neural activity:
Wireless neurophys
Optogenetics
Chemogenetics
Neurosurgery
Director
Dr. Sébastien Tremblay completed his Masters studies in psychology at Université de Montréal and his Ph.D. in neuroscience at McGill University. He went on to pursue a first fellowship at the Montreal Neurological Institute and a second one at the Perelman School of Medicine at the University of Pennsylvania. He is passionate about combining psychology, engineering, and neurosurgery to further the understanding of the brain and develop new tools to treat patients with mental disorders.
TEAM
We are currently building a new team of top scientists
(see 'Join the Lab' below)
VALUES
Scientific Rigor
Searching for the truth, whatever it might be, with the best tools available
Ecological Validity
Making sure our findings have value beyond the laboratory
Cross Disciplinarity
Problems in one discipline have often been solved in another discipline
Open Science
Collaboration over competition, for the benefit of the community
PUBLICATIONS
Key Publications
Testard, C.*, Tremblay, S.*, et al. (2024) Neural signatures of natural behavior in socializing macaques. Nature link *equal contributions
Bohlen, M. & Tremblay, S. (2023) Considerations for the use of viral vectors in NHP experiments, in Vectorology for Optogenetics and Chemogenetics, NeuroMethods, Springer Nature link
Tremblay, S.*, Testard, C.*, DiTullio, R., Inchauspé, J., Petrides, M. (2023) Neural cognitive signals during spontaneous movements in the macaque. Nature Neuroscience link
Tremblay, S., International Consortium of NHP users, Shenoy, K., DiCarlo, J., Platt, M. (2020) An Open Resource for Non-human Primate Optogenetics. Neuron link
Tremblay, S., Sharika, K.M., Platt, M.L. (2017) Social decision-making and the brain: A comparative perspective. Trends in Cognitive Sciences link
Other Publications
Chiou, K., Huang, X., Bohlen, M., Tremblay, S., O’Day, D., Spurrell, C., Gogate, A., Zintel, T., Cayo Biobank Research Unit, Andrews, M., Martínez, M., Starita, L., Montague, M., Platt, M.L., Shendure, J., Snyder-Mackler, N. (2023) A single-cell multi-omic atlas spanning the adult rhesus macaque brain. Science Advances
Salimando, G.J., Tremblay, S., Kimmey, B.A. et al. (2023) Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types. Nature Communications.
Chiou, K.L.*, DeCasien, A.R.*, Rees, K., Testard, C., Spurrell, C.H., Gogate, A.A., Pliner, Tremblay, S., et al. (2022) Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment. Nature Neuroscience
Testard, C. Tremblay, S., Platt, M. (2021) From the field to the lab and back: neuroethology of primate social behavior. Current Opinion in Neurobiology
Tremblay, S., Pieper, F., Sachs, A., Joober, R., Martinez-Trujillo, J.C. (2019) The effects of methylphenidate (Ritalin) on the neurophysiology of the monkey caudal prefrontal cortex. eNeuro
Tremblay, S., Desjardins, M., Bermudez, P., Iturria-Medina, Y., Evans, A.C., Jolicoeur, P., De Beaumont, L. (2019) Mild traumatic brain injury: The effect of age at trauma onset on brain structure integrity. NeuroImage: Clinical
Tremblay, S., Iturria-Medina, Y., Mateos-Pérez, J.M., Evans, A.C., De Beaumont, L. (2017) Defining a multimodal signature of remote sports concussions. European Journal of Neuroscience
Henry, L.C., Tremblay, S., De Beaumont, L. (2016) Long-term effects of sports concussions: Bridging the neurocognitive repercussions of the injury with the newest neuroimaging data. The Neuroscientist
Tremblay, S., Pieper, F., Sachs, A., Martinez-Trujillo, J.C. (2015) Attentional filtering of visual information by neuronal ensembles in the primate lateral prefrontal cortex. Neuron link
Tremblay, S., Doucet, G., Pieper, F., Sachs, A., Martinez-Trujillo, J.C. (2015) Single-trial decoding of visual attention from local field potentials in the primate lateral prefrontal cortex is frequency- dependent. The Journal of Neuroscience
Beaulé, V., Tremblay, S., Lafleur, L.F., Tremblay, S., Lassonde, M., Lepage, J.F., Théoret, H. (2015) Cortical thickness in adults with agenesis of the corpus callosum. Neuropsychologia
Tremblay, S., Henry, L.C., Bedetti, C., Larson-Dupuis, C., Gagnon, J.F., Evans, A.C., Théoret, H., Lassonde, M., De Beaumont, L. (2014) Diffuse white matter tract abnormalities in aging but clinically normal retired athletes with a history of sports-related concussions. Brain
Tremblay, S., Beaulé, V., Proulx, S., Tremblay, S., Marjanska, M., Doyon, J., Lassonde, M., Théoret, H. (2014) Multimodal assessment of primary motor cortex integrity following sport concussion in asymptomatic athletes. Clinical Neurophysiology
Tremblay, S., De Beaumont, L., Henry, L.C., Boulanger, Y., Evans, A.C., Bourgouin, P., Poirier, J., Théorêt, H., Lassonde, M. (2013) Sports concussions and aging: a neuroimaging investigation. Cerebral Cortex
De Beaumont L., Tremblay, S., Théoret, H., Lassonde, M. (2013) Motor system alterations in retired former athletes: the role of aging and concussion history. BMC Neurology
De Beaumont, L., Tremblay, S., Poirier, J., Lassonde, M., Théorêt, H. (2012) Altered bidirectional plasticity and reduced implicit motor learning in concussed athletes. Cerebral Cortex
Henry, L.C., Tremblay, S., Leclerc, S., Khiat, A., Boulanger, Y., Ellemberg, D., Lassonde, M. (2011) Metabolic changes in concussed American football players during the acute and chronic post-injury phases. BMC Neurology
Henry, L.C., Tremblay, J., Tremblay, S., Lee, A., Brun, C., Lepore, N., Théorêt, H., Ellemberg, D., Lassonde, M. (2011) Acute and chronic changes in diffusivity measures after sports concussion. Journal of Neurotrauma
Thériault, M., De Beaumont, L., Tremblay, S., Lassonde, M., Jolicoeur, P. (2011) Cumulative effects of concussions in athletes revealed by electrophysiological abnormalities on visual working memory. Journal of Clinical and Experimental Neuropsychology
De Beaumont, L., Mongeon, D., Tremblay, S., Messier, J., Prince, F., Leclerc, S., Lassonde, M., Théoret, H. (2011) Persistent motor system abnormalities in formerly concussed athletes. Journal of Athletic Training
Henry, L.C.*, Tremblay, S.*, Boulanger, Y., Ellemberg, D., Lassonde, M. (2010) Neurometabolic changes in the acute phase following sports concussions correlate with symptom severity. Journal of Neurotrauma
De Beaumont, L., Théoret, H., Mongeon, D., Messier, J., Leclerc, S., Tremblay, S., Ellemberg, D., & Lassonde, M. (2009) Brain function decline in healthy retired athletes who sustained their last sports concussion in early adulthood. Brain
Access Google Scholar for full bibliography and links
JOIN THE LAB
We are always looking for motivated, curious, and hard-working people from all backgrounds willing to contribute to cutting-edge neuroscience.
Some of the skills that can give you a head start:
Computer programming (Matlab, Python, R, etc.)
Statistics and machine learning
Electrical engineering
Experimental laboratory skills
Medical or veterinary skills
If you are interested in a position, please send your CV and a brief 250 word description of a question you are passionate about at recruitingTNLlab at gmail com.
Contact
The laboratory is located at the CERVO Research Center within Université Laval in Québec City, Canada. We can be reached at questionsTNLlab at gmail com for questions and collaborations.
